Effect of estradiol on histopathology of brain in unilateral and bilateral ovariectomized rats

Estradiol, a major form of estrogen, plays crucial role in various aspects brain function, including neuronal health, synaptic plasticity, and cognitive processes. Therefore, it is interest to investigate the histopathological changes rat following estradiol treatment unilateral bilateral ovariectomized rats, commonly used method induce estrogen deficiency study consequences hormonal changes. Two months old Wistar albino female rats were divided into five experimental groups, each consisting 6 animals. Unilateral treated with (10 mg/Kg/b.wt) subcutaneously for 30 days. The analysis revealed normal 5–6 compact layers small pyramidal cells CA3 region, most vesicular nuclei control andan irregular disturbed thickness cell layer suggesting loss rats. Estradiol therapy these showed dark hyperchromatic which displayed less shrinkage. Bilateral without region Similar Group II, indicating no significant These findings highlight potential modulating associated ovariectomy. Further research warranted elucidate underlying mechanisms through exerts its effects on integrity explore therapeutic strategies preventing or reversing histological